Under the watchful eyes of Father Silvano Bentivoglio and Dr. Vittoria Vetra, the European Organization for Nuclear Research (CERN) initiates the Large Hadron Collider and captures three vials of antimatter. Immediately afterward, someone kills Father Silvano, using his retina to infiltrate the containment chamber, and steals one vial.

The Roman Catholic Church mourns the death of Pope Pius XVI in Rome. Vatican City prepares for the College of Cardinals' papal conclave, which will select the next Pope. Until that time, Camerlengo Patrick McKenna, a papal court official and former helicopter pilot, assumes temporary control of the Vatican. Reporters, nuns, priests, and other faithful members of the Church crowd into Saint Peter's Square, waiting for the white smoke from the conclave, signalling a successful vote. But the Illuminati, a 400-year old, underground secret society, kidnap the four most likely candidates before the conclave enters seclusion. The Illuminati threaten to kill one every hour, beginning at 8:00 pm, and then destroy the Vatican in a burst of light at midnight. A stolen security camera shows the missing antimatter vial, which will catastrophically explode when the vial's battery dies and the magnetic containment field fails.
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